Figure 1.

Screening Early-Stage-Specific lncRNAs in LUAD

The flowchart of WGCNAs and lncRNAs screening (A). 7,320 differentially expressed genes screened from the TCGA LUAD project (B). Hierarchical clustering of 508 LUAD cancer tissue samples based on 7,320 differentially expressed genes (C). 12 significant co-expression gene modules across all 508 sampling sets were demonstrated with WGCNA TOMplot. Identified co-expression modules were represented by color classifiers (gray is assigned to genes that are not part of any module) (D). PCC between the MEs and TNM stages. A positive value indicates that the genes within a particular co-expression module increase as the variable increases, and each PCC value is accompanied by the corresponding p value in brackets (left panel). The heatmap of all 541 differentially expressed lncRNAs in GSE19804 (top panel); screened 59 lncRNAs were subjected to the correlation heatmap (bottom panel) (E).