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. 2019 Apr 13;16:554–565. doi: 10.1016/j.omtn.2019.04.005

Figure 3.

Figure 3

EZH2-Mediated Silencing of miR-124 and MEG3

(A) Hierarchical clustering and heatmap analysis of GSE47476, GSE26996, and one publication from GEO and GCBI database; 13 EZH2-mediated silence miRNAs were identified. (B) DZNep and siRNA to knock down EZH2, which could also inhibit the trimethylation of H3K27 and reduces EZH2 expression. (C) The model of EZH2 induced the epigenetic silencing of miR-124 and MEG3 expression by H3K27me3. (D) Silencing EZH2 using DZNep induced miR-124 and MEG3 expression. (E) Silencing EZH2 using EZH2 siRNA induced miR-124 and MEG3 expression. Data were presented as mean ± SD (*p < 0.05). (F) Pearson correlation coefficient analysis of the expression of miR-124 and MEG3 both were negatively correlated with EZH2 expression in RCC tissues.