Skip to main content
. 2019 Mar 30;116(9):1769–1786. doi: 10.1016/j.bpj.2019.03.020

Figure 9.

Figure 9

Modeled LCM changes driven by OHC transduction OP change. (A) OHC transduction curve based on two-state Boltzmann model is shown. Experimental data were from expt705 in response to 10–90 dB SPL 9 kHz stimuli 8 min after furosemide injection (data shown in Fig. 11 below). (B) Model-predicted second harmonics of LCM (referenced to fundamental amplitude) versus OP change are shown. The amplitude change shows a V-shape that is steeper at higher stimulus levels (solid line: 65 dB SPL; dashed line: 75 dB SPL). (C) Model-predicted phase of second harmonic relative to fundamental versus OP is shown. Phase is right-angled line, and large insets illustrate the meaning. The second harmonic and the fundamental are either in phase (left side, phase difference of zero) or out of phase (right side, phase difference of π = 1/2 cycle) depending on whether the OP is negative or positive. (D–I) OHC transduction curve (D, F, and H) and modeled LCM waveform with pure tone stimuli (E, G, and I; solid line: 65 dB SPL; dashed line: 75 dB SPL) in three different OP cases (0, −0.3, and 0.3 Pa) are shown. At the stimulus level used for this illustration, the LCM is approximately sinusoid when OP = 0 (E) and is distorted when OP moves away from 0 (G and I).