Tilt angle evolution of the DCD oligomer in DMPC (red), DPPC (black), and DSPC (blue) bilayers as observed in the atomistic simulations. (A) The tilt angle evolution in the single-layer simulations is shown, with the initial channel axis normal to the bilayer surface and (B) the tilt angle evolution in the double-layer simulations in which the initial configurations were taken from the single-layer simulations at 200 ns for DMPC and DSPC and at 400 ns for DPPC, as shown in (A). The solid and dashed lines in (B) represent the two channels in the two bilayers of the double-patch CE systems, respectively. To see this figure in color, go online.