Table 2.
Comparison of Geometrical Parameters for Published Complete Antibody Structures
| Antibody | Subclass | PDB Entry | Elbow Angle FabHL/FabKM | Rotation Angle FabHL to FabKM | Angle between Major Axis of Fabs | Angle between Fab-Dyad and Fc | Angle between Fc and FabHL/FabKM | Radius of Gyration/Å |
|---|---|---|---|---|---|---|---|---|
| b12 | human IgG1 | 1hzh | 174°/168° (a) | 176° | 143° (a) | 174° | 109°/105° | 52.3 |
| Mab 61.1.3 | murine IgG1κ | 1igy | 155°/155° (b) | 180° (b) | 115° (b) | 107° (b) | 78°/123° (b) | 46.9 |
| Mab231 | murine IgG2aκ | 1igt | 159°/143° (c) | 176° | 168° | 128 | 65°/115° (c) | 53.8 |
| Mcg | human IgG1 | 1mco | 118°/118° (d) | 176° | 168° | 179 | 84°/84° | 46.8 |
| Pembrolizumab | IgG4 S228P | 5dk3 | 137°/167° (e) | 177° | 105° | 139 | 90°/161° | 46.4 |
| Anti-NPRA | IgG4 S228P | 6gfe | 138°/134° | 177° | 149° | 105 | 24°/168° | 48.6 |
Values for a(6), b(7), c(5), d(8), e(9), and anti-NPRA were calculated from deposited x-ray crystal structures according to Rupp et al. (30).