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. Author manuscript; available in PMC: 2019 Nov 7.
Published in final edited form as: Pharm Res. 2018 Nov 7;36(1):3. doi: 10.1007/s11095-018-2541-z

Figure 7: Formation of granulomas are necessary for the increased IL-1RA production within the liver of CFZ-treated mice.

Figure 7:

A) Liver cryosections of PBS or clodronate treated mice fed a control diet or CFZ-supplemented diet stained for F4/80 (green) and showing CLDI fluorescence. Treatment with clodronate reduces hepatic macrophages, resulting in reduced granuloma size and CLDI accumulation within the granuloma. B) IL-1RA production is inhibited within clodronate-CFZ treated mice, while it is significantly elevated in the PBS-CFZ treatment group. C) The granulomas which form ultimately are responsible for the production of IL-1RA, producing similar levels of IL-1RA to whole-organ homogenates. Scale bar is 50 um. (n=3-4 liver homogenates or isolated granulomas per treatment group) (*=p<0.05, ANOVA, Tukey’s HSD)