Table 4.
Comparison of tumor responses according to the RECIST and EORTC criteria
| Tumor response by the RECIST | Tumor response by the EORTC |
Total | |||
|---|---|---|---|---|---|
| CMR | PMR | SMD | PMD | ||
| CR | 5 | 0 | 0 | 0 | 5 |
| PR | 6 | 46 | 3 | 1 | 56 |
| SD | 3 | 53 | 25 | 12 | 93 |
| PD | 0 | 1 | 7 | 54 | 62 |
| Total | 14 | 100 | 35 | 67 | 216 |
The level of concordance of tumor responses between the EORTC criteria and RECIST is 0.447 (unweighted κ, 95% confidence interval, 0.356 to 0.537). The overall response rates were significantly different between the two criteria (28.2% by RECIST vs. 52.8% by EORTC, p < 0.0001).
RECIST, Response Evaluation Criteria in Solid Tumors; EORTC, European Organization Research and Treatment of Cancer; CMR, complete metabolic response; PMR, partial metabolic response; SMD, stable metabolic disease; PMD, progressive metabolic disease; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.