Figure 4.

Residue Interaction Connectivity in Catalytic Loops of ASD- and Cancer-Associated Mutations

Connectivity in (A) the P loop (residues 123–131), (B) the WPD loop (residues 88–98), and (C) the TI loop (residues 160–171). The size and color of the nodes within the residue-interaction network indicate the importance of the hub node in the network, revealing it as a key player in structural communication (e.g., expansion in size and progression toward red color indicate increasing connectivity).