Table 3.

Summary of Main Findings in Germline PTEN Missense Mutations Associated with ASD Versus Mutations Associated with Cancer

Autism Spectrum Disorder	Cancer
open active site	closed active site
significant network centrality peaks in N-terminal and inter-domain interface	significant network centrality peaks across both domains and inter-domain interface
phosphatase-restricted structural communication pathway	long-range structural communication pathway – nodes in active-site and inter-domain region