Figure 3.
Expression Data and Possible Mechanism Involving CNOT1 in Pancreatic Development
(A) Graphs showing relative expression of genes in the pancreas of E14.5 embryos. Bars show mean ± SE. Data analyzed using ANOVA with TukeyHSD posthoc test. Results of posthoc tests shown on graphs, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. Shh, effect of genotype p = 0.0107; Pdx1, effect of genotype p = 0.0189; Ins, effect of genotype p = 7.03 × 10−6; Hnf1b, effect of genotype p = 0.0294; Ptf1a, effect of genotype p = 0.00781; Gata6, effect of genotype p = ns. n = 4–12 animals per genotype.
(B) Schematic representation of the proposed role for CNOT1 in pancreatic development.