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. 2019 May 8;76(9):958–965. doi: 10.1001/jamapsychiatry.2019.0864

Figure. Reduction in Anhedonia Severity and Mediation of the Association Between Left Ventral Striatum Activation to Reward Prediction Error (RPE) and Improvement in Life Satisfaction.

Figure.

A, Activation to RPE in the ventral striatum, amygdala, and anterior cingulate cortex. B, Left ventral striatum activation to RPE is associated with a decrease in anhedonia (Snaith Hamilton Pleasure Scale [SHAPS] score) severity during a 6-month period. C, Reduction in anhedonia severity at 6 months mediates the association between left ventral striatal activation during RPE and 6-month improvement in life satisfaction. a Path indicates the association between left ventral striatum blood oxygen level–dependent (BOLD) response and change in anhedonia symptoms over 6 months; ab path, the indirect association of the mediation model; b path, the association between the reduction in anhedonia symptoms over 6 months and the improvement in life satisfaction over 6 months; and LIFE-RIFT, Range of Impaired Functioning Tool.