Table 3. Association of Neural Activation to RPE With Change in Self-reported Affective Symptoms Between Baseline and 6 Months.

Affective Symptom	β (95% CI)	P Value
Anhedonic depression (MASQ-AD)
Left ventral striatum	−0.079 (−0.792 to 0.545)	.80
Left amygdala	−0.360 (−0.782 to 0.062)	.09
Left ACC	−0.231 (−0.795 to 0.333)	.41
Right ventral striatum	0.225 (−0.332 to 0.783)	.42
Right ACC	0.398 (−0.257 to 1.054)	.23
Anxious arousal (MASQ-AA)
Left ventral striatum	−0.029 (−0.466 to 0.409)	.89
Left amygdala	−0.058 (−0.361 to 0.238)	.69
Left ACC	−0.120 (−0.521 to 0.275)	.54
Right ventral striatum	0.025 (−0.365 to 0.416)	.90
Right ACC	0.018 (−0.456 to 0.478)	.94
Anhedonia (SHAPS)
Left ventral striatum	−6.152 (−11.870 to −0.433)	.04
Left amygdala	−1.451 (−5.318 to 2.416)	.45
Left ACC	−3.485 (−8.649 to 1.679)	.18
Right ventral striatum	4.790 (−0.319 to 9.899)	.07
Right ACC	4.129 (−1.876 to 10.134)	.17

Abbreviations: ACC, anterior cingulate cortex; MASQ-AA, Mood and Anxiety Symptom Questionnaire–Anxious Arousal subscale; MASQ-AD, Mood and Anxiety Symptom Questionnaire–Anhedonic Depression subscale; RPE, reward prediction error; SHAPS, Snaith Hamilton Pleasure Scale.