Table 2. Odds Ratios of Poor Outcomes of IS Patients vs IC Controls Stratified by Number of Tumors and Adjusted for Brigham and Women's Hospital (BWH) and American Joint Committee on Cancer, 8th Edition (AJCC-8)a Staging Criteria.
| SCCs, No. | LR | NM | ITM | Any PO | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Unadjusted | ||||||||
| 1 | 0.51 (0.11-2.35) | .39 | 7.18 (0.64-81.06) | .11 | 3.57 (0.49-26.06) | .21 | 1.07 (0.33-3.45) | .91 |
| 2-9 | 10.82 (2.31-50.71) | .002 | NA | NA | NA | NA | 11.95 (2.56-55.76) | .002 |
| Adjusted for BWH stage | ||||||||
| 1 | 0.53 (0.11-2.47) | .05 | 10.00 (0.81-123.99) | .07 | 4.88 (0.60-39.91) | .14 | 1.15 (0.35-3.81) | .82 |
| 2-9 | 11.62 (2.33-57.81) | .003 | NA | NA | NA | NA | 13.52 (2.69-67.97) | .002 |
| Adjusted for AJCC-8 stage | ||||||||
| 1 | 0.54 (0.12-2.52) | .44 | 9.35 (0.78-112.41) | .08 | 4.83 (0.61-38.26) | .14 | 1.16 (0.35-3.80) | .81 |
| 2-9 | 11.55 (2.40-55.58) | .002 | NA | NA | NA | NA | 13.29 (2.74-64.47) | .001 |
Abbreviations: IC, immunocompetent patients; IS, immunosuppressed; ITM, in-transit metastases; LR, local recurrence; NA, not applicable; NM, nodal metastases; PO, poor outcomes; SCC, squamous cell carcinoma.
a
The AJCC-8 adjusted odds ratios were calculated for tumors limited to the head and neck region.