Table 2.

Summary of types of first event, as reported for the 974 ‘registration cohort’ patients in whom an EFS was reported.

Type of event	N	%
New metastases	521	53
Combination of events	144	15
New metastases/progression of existing metastases	58	40
Local recurrence/new metastases	52	36
Local recurrence/new metastases/progression of existing metastases	13	9
Other or unknown combination	21	15
Progression of existing metastatic disease	89	9
Local progression	74	8
Local recurrence	70	7
Death without any previously reported progression	41	4
Cause of death attributed to osteosarcoma/treatmenta	32	78
Other cause of death	9	22
Secondary malignancy	26	3
Unknown event type	9	1
Total	974	100

^aOr implicitly attributed to osteosarcoma/treatment as death occurred during therapy.