Figure 5.

Gpc4 KO Mice Exhibit Nasodigital Deficits

(A) Example radiographs showing typical skull morphology of adult WT (left) and Gpc4 KO (right) mice. Note the shortened snout in the KO mouse. Quantification of radiograph data demonstrated that Gpc4 KO mice have significantly shorter snouts; snouts were measured from the tip of the snout to the cranial aspect. However, there is no difference in the intra-orbital distance in Gpc4 KO mice compared to WT.

(B) Gpc4 KO mice have significantly shorter front and rear paws.

n = 7 animals per group; data combine right and left paw to give 14 measurements; statistical comparisons were made with a two-tailed t test; error bars represent mean ± SEM.