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. 2019 May 9;19:96. doi: 10.1186/s12874-019-0738-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic diagram of the optimal equal-HR method. The solid black line presents the U-shaped relationship between the continuous x and log relative hazard. The red dashed line is parallel to the x-axis, which means P₁ and P₂ have equal log relative hazard values. The optimal equal-HR method searches pairs of cut-points with equal log relative hazard values as candidate cut-points, such as (P₁, P₂)