Table 5.

Publication bias on therapeutic efficacy indexes (CR, PR, SD, PD, ORR, DCR and QIR) and adverse events indexes (Nausea and vomiting, Diarrhea, Leucopenia, Anemia and Neurotoxicity)

Publication Bias	Therapeutic efficacy							Adverse events
CR	PR	SD	PD	ORR	DCR	QIR	Nausea and vomiting	Diarrhea	Leucopenia	Anemia	Neurotoxicity
Begg	0.742	0.038	0.513	0.870	0.280	0.870	0.304	0.161	0.755	0.003	0.454	1.000
Egger	0.833	0.015	0.721	0.905	0.331	0.905	0.235	0.069	0.623	<0.0001	0.528	0.894

Note: Parameters discussed in over 8 papers were conducted bias analyses.

Abbreviations: CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; ORR, overall response rate; DCR, disease control rate; QIR, quality of life improved rate.