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. 2019 Mar 13;39(11):2080–2090. doi: 10.1523/JNEUROSCI.2701-18.2019

Figure 3.

Figure 3.

Working memory actions of caudal dmPFC CRF neurons are dependent on local CRF receptors coupled to PKA. A, Intra-PFC infusion of the nonselective CRF antagonist d-Phe-CRF (100 ng/hemisphere) blocks the working memory-impairing effects of chemogenetic activation of caudal dmPFC CRF neurons (3 mg/kg CNO; n = 9). B, Intra-PFC infusion of the PKA inhibitor Rp-cAMPs (20 nm/hemisphere) also blocks the working memory-impairing effects of 3 mg/kg CNO (n = 5). Results are mean ± SEM percentage change in accuracy relative to baseline. *p < 0.05. **p < 0.01. ***p < 0.001.