Figure 9.

Model of Cenpj function in neurogenesis in the developing neocortex. Depletion of Cenpj causes long primary cilia and abnormal appendages of RG cells at the embryonic stage, resulting in NPC cycle blockage and cell death. At the adult stage, depletion of Cenpj contributes to long thin motile cilia with curly tips on the ependymal cells and long primary cilia on the B cells. Abnormal arrangement of the microtubule doublets and disorganized cilia appendages were also observed. We show that Cenpj regulates cilia disassembly and neurogenesis through Kif2a.