Table 3.
Association between potential prognostic factors and outcome (n = 177 pregnancies)
| Potential prognostic factor | Unadjusted OR (95%CI) | Adjusted* OR (95%CI) | p value | Change in c-statistic† |
|---|---|---|---|---|
| Fetal adverse outcome composite | ||||
| NT (% discordance) | 1.03 (1.01, 1.05) | 1.03 (1.01, 1.06) | 0.011 | 0.045 |
| CRL (% discordance) | 1.16 (1.06, 1.27) | 1.17 (1.07, 1.29) | 0.001 | 0.103 |
| AFP | 1.91 (0.93, 3.94) | 2.08 (0.94, 4.59) | 0.071 | 0.026 |
| sFlt-1 | 1.12 (0.52, 2.40) | 1.03 (0.42, 2.50) | 0.950 | < 0.001 |
| PlGF | 0.73 (0.44, 1.22) | 0.65 (0.37, 1.13) | 0.125 | 0.014 |
| Twin-twin transfusion syndrome (TTTS) | ||||
| NT (% discordance) | 1.05 (1.02, 1.08) | 1.06 (1.03, 1.10) | < 0.001 | 0.137 |
| CRL (% discordance) | 1.07 (0.96, 1.20) | 1.09 (0.97, 1.23) | 0.161 | 0.032 |
| AFP | 3.04 (1.05, 8.78) | 3.24 (1.00, 10.48) | 0.050 | 0.067 |
| sFlt-1 | 1.91 (0.62, 5.88) | 1.64 (0.44, 6.03) | 0.459 | 0.006 |
| PlGF | 0.43 (0.20, 0.91) | 0.42 (0.19, 0.93) | 0.032 | 0.074 |
| Antenatal growth restriction | ||||
| NT (% discordance) | 1.01 (0.99, 1.03) | 1.01 (0.99, 1.04) | 0.261 | 0.014 |
| CRL (% discordance) | 1.17 (1.06, 1.30) | 1.20 (1.08, 1.34) | 0.001 | 0.119 |
| AFP | 1.55 (0.67, 3.55) | 2.10 (0.82, 5.40) | 0.123 | 0.032 |
| sFlt-1 | 1.25 (0.50, 3.13) | 1.47 (0.49, 4.35) | 0.491 | 0.011 |
| PlGF | 0.91 (0.50, 1.66) | 0.88 (0.44, 1.76) | 0.720 | −0.001 |
| Single intrauterine fetal death (sIUFD) | ||||
| NT (% discordance) | 1.01 (0.98, 1.05) | 1.02 (0.98, 1.06) | 0.425 | <−0.001 |
| CRL (% discordance) | 1.17 (1.00, 1.36) | 1.19 (1.01, 1.40) | 0.035 | 0.085 |
| AFP | 0.68 (0.16, 2.87) | 0.80 (0.17, 3.90) | 0.787 | −0.004 |
| sFlt-1 | 1.27 (0.27, 6.04) | 1.79 (0.30, 10.64) | 0.523 | <−0.001 |
| PlGF | 0.35 (0.13, 0.97) | 0.34 (0.12, 0.98) | 0.045 | 0.057 |
| Double intrauterine fetal death (dIUFD) | ||||
| NT (% discordance) | 1.02 (0.98, 1.06) | 1.02 (0.98, 1.06) | 0.420 | −0.005 |
| CRL (% discordance) | 1.06 (0.91, 1.24) | 1.12 (0.94, 1.33) | 0.221 | 0.019 |
| AFP | 1.33 (0.34, 5.21) | 0.97 (0.18, 5.33) | 0.970 | <−0.001 |
| sFlt-1 | 4.13 (0.92, 18.58) | 8.21 (1.02, 66.24) | 0.048 | 0.035 |
| PlGF | 0.23 (0.08, 0.63) | 0.18 (0.05, 0.58) | 0.005 | 0.080 |
The AFP, sFlt-1, and PlGF are loge transformed
*Adjusted for maternal BMI, age, smoking status, ethnicity, parity, and mode of conception. sIUFD and dIUFD were only able to be adjusted for maternal BMI, age, ethnicity, and mode of conception. Italics denote significant associations. P value is related to the adjusted OR
†Change in c-statistic represents the additional prognostic value of each individual potential prognostic factor above the standard prognostic factors (maternal BMI, age, smoking status, ethnicity, parity, and mode of conception). The baseline c-statistics for the fetal adverse outcome composite is 0.594, TTTS is 0.617, antenatal growth restriction is 0.616, sIUFD is 0.625, and dIUFD is 0.783