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. 2019 May 9;11:73. doi: 10.1186/s13148-019-0674-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Correlation between chronological GA and epigenetic GA. Chronological GA was calculated using first-trimester crown-rump length measurement of the larger twin, and epigenetic age was calculated based on DNA methylation-based Knight’s clock. Both GA estimations were significantly correlated (r = 0.76; p = 1.68 × 10⁻¹²)