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. 2019 Apr 24;2019:5696801. doi: 10.1155/2019/5696801

Figure 1.

Figure 1

Downregulated survivin expression in hypoxic laryngeal carcinoma cells transfected with survivin-siRNA. AMC-HN-8 and Hep-2 cells were transfected with either a vector carrying a survivin targeting sequence (survivin-siRNA) or a vector carrying a survivin scrambled. Cells were cultured in hypoxia for 24 hours. By real-time quantitative RT-PCR, survivin mRNA expression in cells was detected; ∗∗P < 0.01 vs. negative and empty groups in hypoxia (a). The expression of survivin protein in Hep-2 (b) and AMC-HN-8 (c) cell lines was measured by Western blot analysis.