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. 2019 Apr 4;8(8):e010823. doi: 10.1161/JAHA.118.010823

Figure 2.

Figure 2

Cx37−/− mice become rapidly normotensive after the 2K1C procedure. A, One month after the 2K1C surgery, WT mice were significantly hypertensive, compared with their sham‐operated controls, whereas Cx37−/− mice featured a control SBP (systolic blood pressure). WT sham (sham‐operated controls) N=15; Cx37−/− sham N=14; WT 2K1C (2‐kidney, 1‐clip) N=19; Cx37−/− 2K1C N=17. B, Compared with controls infused with NaCl, both WT and Cx37−/− mice showed a significant increase in SBP after a daily infusion of 0.25 mg Ang II/kg body weight during 1 month. However, this increase was significantly lower in Cx37−/− than in WT mice. WT NaCl, Cx37−/− NaCl N=7; WT Ang II (angiotensin II); Cx37−/− Ang II N=8. C, In contrast, the mice of these 2 genotypes showed a similar increase in blood pressure, after a daily treatment with l‐NAME (N‐nitro‐l‐arginine‐methyl‐ester, 500 mg/L in the drinking water) for 1 month. N=6. Results are means+SEM. *P≤0.05 and ***P≤0.001 vs respective control mice; °°° P≤0.001 vs WT mice, as given by 2‐way ANOVA. Ang II indicates angiotensin II; Cx37, connexin37; n.s., not significant; WT, wild type.