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. 2019 Apr 4;8(8):e010823. doi: 10.1161/JAHA.118.010823

Figure 5.

Figure 5

Loss of Cx37 selectively alters the expression of some Ang II‐stimulated signals. The levels of transcripts coding for Angiotensinogen (Agt), Angiotensin receptor 1a (Agtr1a), and Angiotensin receptor 1b (Agtr1b) were similar in the aortas of WT and Cx37−/− mice. In contrast, the transcripts coding for Angiotensin receptor 2 (Agtr2), Connector enhancer of kinase suppressor of Ras 1 (Cnksr1), SH2 domain‐containing tyrosine phosphatase 2 (Ptpn6), and Glutamyl aminopeptidase A (Enpep), which all contribute to control the Ang II pathway, were increased in the aortas of Cx37−/− mice. N=9. Results are means+SEM. *P≤0.05, ***P≤0.001 vs WT mice, as given by t test. Ang II indicates angiotensin II; Cx37, Connexin37; WT, wild type.