Figure 7.

Loss of Cx37 does not alter the expression of several signals involved in the Ang II effects. The levels of transcripts coding for the chymase (Cma1), which converts Ang I to Ang II, the Regulator of G‐protein signaling 2 (Rgs2), which negatively regulates AT1R function by modulating its Gαq subunit activity, the Dual specificity protein phosphatase 1 (Dusp1), an AT2R‐associated phosphatase that contributes to AT2R‐mediated inactivation of the ERK cascade, and Mas1, the receptor for Ang‐(1–7) that promotes vasodilatation, were similar in the aortas of WT and Cx37−/− mice. WT N=9; Cx37−/− N=8. Results are means+SEM. Statistical analysis was performed using t test. Ang indicates angiotensin; AT1R, Ang II type 1 receptors; AT2R, Ang II type 2 receptors; Cx37, Connexin37; WT, wild type.