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. 2019 Apr 4;8(8):e010823. doi: 10.1161/JAHA.118.010823

Figure 8.

Figure 8

Loss of Cx37−/− alters the activation of downstream key signaling proteins to the Ang II signaling pathway. A through C, After a 2‐hour exposure to 40 μmol/L Ang II, the levels of phosphorylated ERK (A), MLC2 (B), and AKT (C) increased in the aortas of WT but not of Cx37−/− mice. WT Ctl, WT Ang II N=3; Cx37−/− Ctl, Cx37−/− Ang II N=5. Results are means+SEM. *P≤0.05 vs respective control mice and ° P≤0.05, °° P≤0.01 vs WT mice, as given by 2‐way ANOVA. Ang II indicates angiotensin II; Ctl, control; Cx37, Connexin37; MLC2, myosin light chain 2; WT, wild type.