Table V.

Bacterial species exhibiting significant alterations in relative abundance between TIL-H and TIL-L groups.

Phylum	Class	Order	Family	Genus	Species	Mean, TIL-L (%)	Mean, TIL-H (%)	P-value	FDR
Actinobacteria	Actinobacteria	Actinomycetales	Mycobacteriaceae	Mycobacterium		1.35×10−5	0	7.97×10−6	0.001752485
Actinobacteria	Actinobacteria	Actinomycetales	Nocardiaceae	Rhodococcus		7.45×10−6	0	0.000872455	0.01998002
Actinobacteria	Coriobacteriia	Coriobacteriales	Coriobacteriaceae	Collinsella	Stercoris	7.11×10−5	0	0.000999001	0.01998002
Bacteroidetes	Bacteroidia	Bacteroidales	Bacteroidaceae	Bacteroides	Barnesiae	9.69×10−5	0	0.000999001	0.01998002
Bacteroidetes	Bacteroidia	Bacteroidales	Bacteroidaceae	Bacteroides	Coprophilus	0.012465402	5.90×10−5	0.002997003	0.038784745
Euryarchaeota	Methanobacteria	Methanobacteriales	Methanobacteriaceae	Methanosphaera		0	5.40×10−6	0.001388066	0.025447882
Firmicutes	Erysipelotrichi	Erysipelotrichales	Erysipelotrichaceae	Catenibacterium		7.09×10−5	0	0.000999001	0.01998002
Firmicutes	Clostridia	Clostridiales	Lachnospiraceae	Blautia	Producta	2.71×10−5	0.000354621	0.000999001	0.01998002
Firmicutes	Erysipelotrichi	Erysipelotrichales	Erysipelotrichaceae	Bulleidia		6.88×10−6	0	0.001908364	0.032295398
Firmicutes	Clostridia	Clostridiales	Ruminococcaceae	Anaerofilum		1.43×10−5	2.46×10−6	0.002518182	0.037610265
Firmicutes	Clostridia	Clostridiales	Ruminococcaceae	Ruminococcus	Flavefaciens	1.04×10−5	9.19×10−7	0.002735292	0.037610265
Fusobacteria	Fusobacteriia	Fusobacteriales	Leptotrichiaceae	Sneathia		2.31×10−5	0	0.000999001	0.01998002
Proteobacteria	Alphaproteobacteria	Rhizobiales	Hyphomicrobiaceae	Devosia		1.05×10−5	0	3.81×10−5	0.004192394
Proteobacteria	Deltaproteobacteria	Desulfovibrionales	Desulfovibrionaceae	Desulfovibrio	C21_c20	9.42×10−6	0	0.00018235	0.013372361
Proteobacteria	Gammaproteobacteria	Aeromonadales	Succinivibrionaceae	Anaerobiospirillum		0	1.25×10−5	0.000999001	0.01998002
Proteobacteria	Alphaproteobacteria	Rhizobiales	Methylobacteriaceae	Methylobacterium	Komagatae	0	4.99×10−6	0.00262006	0.037610265
Synergistetes	Synergistia	Synergistales	Dethiosulfovibrionaceae	TG5		7.16×10−6	8.63×10−7	0.000499914	0.01998002

The difference of microbial community abundance between the two groups was tested using the Metastats software. The P-value was obtained, then the Q-value was corrected by FDR, and the significance of the difference was evaluated by screening the P-value or Q-value. P≤0.05 indicated a statistically significant difference. FDR, false discovery rate; H, high; L, low; TIL, tumor-infiltrating lymphocytes.