Figure 4.

hERG1 is involved in the pathophysiological processes of SKOV3 cells. (A) Knockdown of hERG1 significantly reduced the cell proliferation activity in SKOV3 cells compared with in control cells. BBR at a concentration of 10 µM was used as a positive control. Quantification of the (B) migration and (C) invasion abilities of SKOV3 cells in different treatment groups. Images (magnification, ×200) represent the (D) migrating cells and (E) invading cells in the Transwell and Matrigel invasion assays, respectively. n=3. *P<0.05, **P<0.01 vs. control. BBR, berberine; hERG1, human ether-a-go-go-related potassium channel 1; IC₅₀, half-maximal inhibitory concentration; sh, short hairpin RNA; OD, optical density.