Figure 5.

Knockdown of hERG1 inhibits ovarian tumor growth in vivo. (A) When tumors reached 100 mm³ in ~1 week, BBR treatment was initiated. Mice in the control group were injected with saline. (B) Body weight of mice with xenografts. No notable difference was detected in the body weight of mice among the four groups. (C) Weight of tumor samples from nude mice. (D) Macroscopic appearance of the tumors at 4 weeks after drug administration. n=3. *P<0.05, **P<0.01 vs. control. BBR, berberine; hERG1, human ether-a-go-go-related potassium channel 1; sh, short hairpin RNA.