Table III.
Univariate binary logistics regression analysis of clinicopathological characteristics with 21-gene recurrence score.
| High/intermediate vs. low risk | |||
|---|---|---|---|
| Clinicopathological characteristics | OR | 95% CI | P-value |
| Age | 0.991 | 0.955–1.028 | 0.616 |
| Tumor discovery time | 1.000 | 0.998–1.001 | 0.664 |
| Occupation | 0.510 | ||
| Manual worker | 1.830 | 0.617–5.423 | 0.276 |
| Skilled worker | 1.152 | 0.399–3.324 | 0.794 |
| Unemployed | Ref | ||
| BMI | |||
| <24 | Ref | ||
| ≥24 | 2.929 | 1.300–6.601 | 0.010 |
| Menopausal state | |||
| Postmenopausal | Ref | ||
| Premenopausal | 1.049 | 0.490–2.245 | 0.902 |
| Tumor size (cm) | |||
| ≤2 | Ref | ||
| >2 | 1.908 | 0.855–4.260 | 0.115 |
| Pathological type | |||
| NIDC | Ref | ||
| IDC | 14.367 | 1.830–112.826 | 0.011 |
| Histological grade | |||
| I–II | Ref | ||
| III | 3.153 | 1.286–7.729 | 0.012 |
| Clinical stage | |||
| Stage I | Ref | ||
| Stage II–III | 1.908 | 0.855–4.260 | 0.115 |
| Molecular type | |||
| Luminal A | Ref | ||
| Luminal B | 2.538 | 1.132–5.692 | 0.024 |
| Surgical scheme | |||
| BCS | Ref | ||
| BMS | 1.182 | 0.397–3.523 | 0.764 |
| P53 (%) | 7.592 | 0.940–61.290 | 0.057 |
| CK5/6 status | |||
| Positive | Ref | ||
| Negative | 0.582 | 0.147–2.304 | 0.441 |
| CEA | 1.076 | 0.747–1.551 | 0.693 |
| CA15-3 | 1.042 | 0.971–1.118 | 0.254 |
Bold indicates P<0.05. BCS, breast conserving surgery; BMI, body mass index; BMS, breast mastectomy surgery; CA15-3, cancer antigen 15-3; CEA, carcinoembryonic antigen; CI, confidence interval; CK5/6, cytokeratin 5/6; IDC, invasive ductal carcinoma; NIDC, non-invasive ductal carcinoma; OR, odds ratio; Ref, reference.