Figure 5.

Forest plots of the incidence risk for grade 3–5 diarrhea. (A1): OR of diarrhea for grade 3–5 in the subgroup analysis (PD-1/PD-L1 vs chemotherapy) (A2): OR of diarrhea for grade 3–5 in the subgroup analysis (PD-1/PD-L1 vs docetaxel/combined chemotherapy), the data included were assigned to the corresponding subgroup according to control group (docetaxel or combined chemotherapy). (A3): OR of diarrhea for grade 3–5 in the subgroup analysis (PD-1/PD-L1 vs chemotherapy), the data included were assigned to the corresponding subgroup according to the name of PD-1/PD-L1 inhibitor and the control group. (B): OR of diarrhea for grade 3–5 in the subgroup analysis (PD-1/PD-L1 + chemotherapy vs chemotherapy).

Abbreviation: PD-1, programmed cell death 1; PD-L1, programmed cell death ligand 1; RE, random effect.