Figure S1.

Funnel plots of the incidence risk for all-grade diarrhea. (A1): Funnel plots of diarrhea for all grades in the subgroup analysis (PD-1/PD-L1 vs chemotherapy). (A2): Funnel plots of diarrhea for all grades in the subgroup analysis (PD-1/PD-L1 vs docetaxel/combined chemotherapy), the data included were assigned to the corresponding subgroup according to control group (docetaxel or combined chemotherapy). (A3): Funnel plots of diarrhea for all grades in the subgroup analysis (PD-1/PD-L1 vs chemotherapy), the data included were assigned to the corresponding subgroup according to the name of PD-1/PD-L1 inhibitor and the control group. (B): Funnel plots of diarrhea for all grades in the subgroup analysis (PD-1/PD-L1 + chemotherapy vs chemotherapy).

Abbreviation: PD-1, programmed cell death 1; PD-L1, programmed cell death ligand 1; OR, odds ratio; RR, risk ratio.