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. 2019 Mar 19;17(6):4811–4818. doi: 10.3892/ol.2019.10164

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Copyright: © Kawashima et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Effect of anti-CD151 antibody on lymphatic invasion of HS-MM^high cells in the xenoplantation mouse model. Anti-CD151 antibody reduced lymphatic invasion at the xenoplant site in severe combined immunodeficient-beige mice and the rate of intraperitoneal dissemination of HS-MM^high cells without affecting local tumor growth. (A) Robust lymphatic infiltration of HS-MM^high cells was evident beneath the local growth site (indicated by arrow). Inoculation of anti-CD151 antibody almost entirely abolished the lymphatic infiltration of HS-MM^high cells. Note a few cells in the lymphatic vessels (indicated by arrow). Original magnification, ×100 (Mock and anti-CD151) and ×400 (anti-CD151, inserted figure). (B) No significant alteration of local growth of HS-MM^high cells was found in the xenoplant assay. (C) Administration of anti-CD151 antibody significantly decreased the total weights of the disseminated mesenteric tumors. Data are expressed as mean ± SD (n=4 for anti-CD151 group, n=3 for Mock group; Student's t-test, **P<0.01 vs. counterpart). CD151, cluster of differentiation 151; SD, standard deviation.