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. Author manuscript; available in PMC: 2019 May 9.
Published in final edited form as: Nature. 2019 Feb 27;567(7749):525–529. doi: 10.1038/s41586-019-0979-8

Extended Data Fig. 5. Deletion of NR4A1 in T cells exacerbates colitis.

Extended Data Fig. 5

a, Wild-type and Nr4a1−/− CD4+CD45RBhi T cells (4 × 10 5 per mouse) were transferred into Rag1−/− mice. Mice were euthanized four weeks after T cell transfer. Donor-derived T cells were collected from the lamina propria and analysed for IFNγ and IL-17A expression by flow cytometry. n = 4 per group. b, Caeca and colons were collected from Rag1−/− mice with wild-type or Nr4a1−/− CD4+ T cells. n = 4 per group. c, Haematoxylin and eosin staining of colon tissues. d. Flow cytometry analysis of donor-derived CD25+FOXP3+ Treg cells in lamina propria (LP), mesenteric lymph nodes (mLN) and spleens (SP) 28 days after T cell transfer. All data are representative of two independent experiments with similar results.