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. Author manuscript; available in PMC: 2020 Mar 19.
Published in final edited form as: Immunity. 2019 Mar 19;50(3):655–667.e4. doi: 10.1016/j.immuni.2019.02.013

Figure 5. Treg cells preferentially regulate cxcl5 expression during epidermal barrier repair.

Figure 5

Cntrl and DT-administered FoxP3DTR mice (Treg cell-depleted) were treated as in Figure 1a, harvested 4 days after skin injury and compared to uninjured mice.

(a) Scatter plot and (b) quantification of chemokines by qRT-PCR array of uninjured WT vs. epidermal injured WT mice.

(c) Scatter plot and (d) quantification of chemokines from injured cntrl vs. injured Treg cell-depleted mice.

(e) Plot and (f) chemokine quantification of uninjured cntrl and uninjured Treg cell-depleted mice.

(g) cxcl5 expression from the indicated sort purified epidermal cells (See also Supplementary Figure 3a for gating strategy).

Representative of 2 independent experiments (n=3 mice per group) Data are +/− SEM *** p< 0.001 comparing cxcl5 expression in panel d versus f by Student’s t-test.