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. 2019 Apr 9;17(6):5343–5350. doi: 10.3892/ol.2019.10235

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — TMZ downregulates SIRT1 expression in glioma cells. (A) The expression of SIRT1 in U251 cells with TMZ treatment was detected by western blotting. (B) RT-qPCR detection of SIRT1 expression in U251 cells treated with different concentrations of TMZ. (C) The expression of SIRT1 in U87 cells treated with TMZ was detected by western blotting. (D) RT-qPCR detection of SIRT1 expression in U87 cells treated with different concentrations of TMZ. **P<0.001 and ***P<0.001 compared with the control group. RT-qPCR, reverse transcription-quantitative polymerase chain reaction; SIRT1, sirtuin 1; TMZ, temozolomide.