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. 2019 Apr 9;17(6):5343–5350. doi: 10.3892/ol.2019.10235

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — SIRT1 knockdown and SIRT1 inhibitor increase glioma cell TMZ sensitivity. (A) The viability of U251 cells treated with different concentrations of TMZ was detected by WST-1 assay. (B) The viability of U87 cells treated with different concentrations of TMZ was detected by WST-1 assay. (C) The viability of U251 cells treated with TMZ or SIRT1 inhibitor was detected by WST-1 assay. (D) The viability of U87 cells treated with TMZ or SIRT1 inhibitor was detected by WST-1 assay. *P<0.05, **P<0.001 and ***P<0.001 compared with the relative untreated group. EX527, selisistat, SIRT1 inhibitor; NC, negative control; shSIRT1, short hairpin RNA SIRT1; SIRT1, sirtuin 1; TMZ, temozolomide; WST-1, water soluble tetrazolium salts 1.