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SIRT1 inhibition increases the generation of reactive oxygen species in glioma. (A) The reactive oxygen species level of U251 cells was detected by DHE staining. Scale bar, 200 µm. (B) Statistical analysis of the DHE fluorescence intensity. ***P<0.001. DHE, dihydroergotamine; EX527, selisistat, SIRT1 inhibitor; NC, negative control; shSIRT1, short hairpin RNA SIRT1; SIRT1, sirtuin 1; TMZ, temozolomide.
