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. 2019 Apr 9;17(6):5343–5350. doi: 10.3892/ol.2019.10235

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — SIRT1 inhibition sensitizes glioma tumors to TMZ in vivo. (A) Determination of nude mice tumor growth. Tumor volume was calculated every 2 days following injection. (B) The expression of SIRT1, Ki67 and p53 in nude mice was detected by western blotting. (C) The relative expression level of SIRT1 in nude mice. (D) The relative expression level of Ki67 in nude mice. (E) The relative expression level of p53 in nude mice. ***P<0.001. EX527, selisistat, SIRT1 inhibitor; NC, negative control; shSIRT1, short hairpin RNA SIRT1; SIRT1, sirtuin 1; TMZ, temozolomide.