Prognostic values of KMT5A and CDH1 for patients with ccRCC, assessed by Kaplan-Meier analyses. (A) High levels of CDH1 were observed in 30.3% of the high-KMT5A group in comparison with 69.0% in the low-KMT5A group. (B) A negative correlation was revealed between the expression levels of KMT5A and CDH1 in ccRCC tissues (r=−0.6506; P<0.001). (C) The patients with ccRCC who exhibited high CDH1 expression were associated with longer OS time compared with the low CDH1 expression group. (D) Patients who had high KMT5A as well as low CDH1 expression levels were associated with the poorest prognosis (the shortest OS time), whereas those with low KMT5A and high CDH1 expression levels had the best prognosis. The ccRCC data was obtained from The Cancer Genome Atlas database (https://tcga-data.nci.nih.gov/publications/tcga). ccRCC, clear cell renal cell carcinoma; KMT5A, N-lysine methyltransferase KMT5A; CDH1, cadherin-1; OS, overall survival.