Table III.
Multivariate analysis of variables potentially associated with overall survival (Cox regression model).
| Variable | HR (95% CI) | P-value |
|---|---|---|
| TNF-α | ||
| HBV infection (no vs. yes) | 3.296 (1.212–8.967) | 0.019 |
| PLT level (<100 vs. ≥100×109 cells/l) | 0.417 (0.188–0.921) | 0.031 |
| TNF-α (both low vs. TNF-α high) | 0.461 (0.213–0.999) | 0.0497 |
| p38MAPK | ||
| p38MAPK (both low vs. p38MAPK high) | 0.332 (0.157–0.702) | 0.004 |
| TNF-α and p38MAPK | ||
| Microvascular tumor thrombus (no vs. yes) | 2.863 (1.141–7.185) | 0.025 |
| TNF-α and p38MAPK (both low vs. both high) | 0.251 (0.108–0.588) | 0.001 |
HR, hazard ratio; CI, confidence interval; TNF-α, tumor necrosis factor α; HBV, hepatitis B virus; PLT, platelet; p38MAPK, p38 mitogen-activated protein kinase.