Table IV.

Multivariate analysis of variables potentially associated with disease-free survival (Cox regression model).

Variable	HR (95% CI)	P-value
TNF-α
Tumor size (≤5 cm vs. >5 cm)	2.340 (1.022–5.356)	0.044
Microvascular tumor thrombus (no vs. yes)	2.411 (1.235–4.707)	0.010
TNF-α (both low vs. TNF-α high)	0.621 (0.444–0.869)	0.005
p38MAPK
Microvascular tumor thrombus (no vs. yes)	2.057 (1.068–3.964)	0.031
p38MAPK (both low vs. p38MAPK high)	0.372 (0.193–0.716)	0.003
TNF-α and p38MAPK
Microvascular tumor thrombus (no vs. yes)	2.500 (1.230–5.079)	0.011
TNF-α and p38MAPK (both low vs. both high)	0.337 (0.166–0.681)	0.002

HR, hazard ratio; CI, confidence interval; TNF-α, tumor necrosis factor α; p38MAPK, p38 mitogen-activated protein kinase.