Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 2;10:332. doi: 10.3389/fgene.2019.00332

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Otsuka, Fukao, Funakami, Duncan and Fujiwara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Functional model of destabilizing ARE-BP, TTP and stabilizing ARE-BP, HuD. (A) TTP induces mRNA decay by recruiting CCR4-NOT complex, exosome complex, and Dcp1a/Dcp2 complex and represses translation by recruiting 4EHP via binding GYF2. (B) HuD stimulates translation via direct binding to eIF4A and the poly(A) tail. miRISC represses translation by dissociation of eIF4A from the translation initiation complex, and this inhibitory effect on translation initiation is attenuated by HuD. HuD also binds Akt/PKB, which phosphorylates destabilizing ARE-BPs such as KSRP, TTP, ZFP36L1, and ZFP36L2 to inactivate them, and eIF4B to stimulate helicase activity of eIF4A.