Figure 2.
Effect of CO extract on cell cycle progression of MDA-MB-231 cells. (A) Treatment with CO results in a progressive dose-dependent increase in the G1: S+G2/M ratio. Results are expressed as the mean ± standard deviation. n=3 per treatment group. Data were analyzed by analysis of variance and Dunnett's test. (B) Effect of CO extract on the RB signaling pathway. Treatment with CO results in a dose-dependent inhibition of cyclin D1 and p-RB protein expression. *P<0.05 vs. control. CO, Cornus officinalis; RB, retinoblastoma; p, phosphorylated; ASU, arbitrary scanning unit.