Figure 3.

Effect of CO extract on apoptosis. (A) Treatment with CO extract results in upregulated expression of BAX gene and downregulated expression of BCL-2 gene. Results are expressed as mean δδ Ct ± SD. n=3 per treatment group. (B) Treatment with CO results in a dose-dependent upregulation of caspase-3/7 activity. Results are expressed as the mean RLU ± SD. n=3 per treatment group. Data were analyzed by ANOVA and Dunnett's test. *P<0.05 vs. respective control. CO, Cornus officinalis; BAX, BCL-2 associated X protein; BCL-2, B-cell lymphoma-2; RLU, relative luminescent unit; ANOVA, analysis of variance; SD, standard deviation.