Table VI.
Histological evaluation at 6 weeks.
| Mean ± standard deviation | |||||
|---|---|---|---|---|---|
| Variable | CTL group | PRP group | PRP + SC group | Kruskal-Wallis P-value | Kruskall Wallis post-hoc multiple comparison with Bonferroni's correction P-value |
| Tissue morphology | 3.83±0.41 | 3.50±0.53 | 3.86±0.38 | 0.216 | – |
| Matrix staining | 3.83±0.41 | 3.40±0.70 | 3.86±0.38 | 0.193 | – |
| Structural integrity | 4.0±0.00 | 3.60±0.52 | 4.00±0.00 | 0.050 | – |
| Chondrocyte clustering in implant | 2.00±0.00 | 1.80±0.42 | 2.43±0.53 | 0.025a | CTL × PRP, P=1,000 |
| CTL × PRP+SC, P=0.699 | |||||
| PRP × PRP+SC, P=0.155 | |||||
| Intactness of calcified layer, formation of tidemark | 1.17±0.41 | 1.90±1.10 | 1.57±0.53 | 0.280 | – |
| Subchondral bone formation | 2.00±0.00 | 2.40±0.52 | 2.29±0.49 | 0.222 | – |
| Histological assessment of surface architecture | 2.00±0.00 | 2.50±0.53 | 3.86±0.38 | <0.001a | CTL × PRP, P=0.675 |
| aCTL × PRP+SC, P=0.001 | |||||
| aPRP × PRP+SC, P=0.015 | |||||
| Histological assessment of defect filling | 4.83±0.41 | 4.50±0.53 | 5.00±0.00 | 0.065 | – |
| Lateral integration of implanted material | 2.00±0 | 2.10±0.32 | 3.00±0 | <0.001a | CTL × PRP, P=1.000 |
| aCTL × PRP+SC, P=0.007 | |||||
| aPRP × PRP+SC, P=0.006 | |||||
| Basal integration of implanted material | 3.00±0 | 3.50±0.53 | 3.43±0.79 | 0.156 | – |
| Inflammation: Maximum total score | 1.00±0 | 1.40±0.84 | 1.00±0 | 0.256 | – |
| Total score | 29.67±1.03 | 30.60±4.30 | 34.29±1.60 | 0.047a | CTL × PRP, P=1,000 |
| CTL × PRP+SC, P=0.062 | |||||
| PRP × PRP+SC, P=0.164 | |||||
a
P<0.05. CTL, control group without treatment; PRP, group treated with platelet-rich plasma; PRP + SC, group treated with platelet-rich plasma plus human dental pulp stem cells.