. 2019 Apr 17;17(6):4344–4356. doi: 10.3892/etm.2019.7499

Table VII.

Histological evaluation at 12 weeks.

	Mean ± standard deviation

Variable	CTL group	PRP group	PRP + SC group	Kruskal-Wallis P-value	Kruskall Wallis post-hoc multiple comparison with Bonferroni's correction P-value
Tissue morphology	3.10±0.32	3.78±0.44	4.0±0.00	0.003^a	^aCTL × PRP, P=0.036
					^aCTL × PRP+SC, P=0.004
					PRP × PRP+SC, P=1.000
Matrix staining	2.90±0.32	3.89±0.33	3.75±0.46	0.002^a	^aCTL × PRP, P=0.002
					^aCTL × PRP+SC, P=0.017
					PRP × PRP+SC, P=1.000
Structural integrity	3.30±0.95	4.22±0.67	4.38±0.52	0.020^a	CTL × PRP, P=0.163
					CTL × PRP+SC, P=0.073
					PRP × PRP+SC, P=1.000
Chondrocyte clustering in implant	1.80±0.42	2.00±0.50	2.63±0.52	0.007^a	CTL × PRP, P=1.000
					^aCTL × PRP+SC, P=0.032
					PRP × PRP+SC, P=0.172
Intactness of calcified layer, formation of tidemark	1.30±0.48	2.67±1.12	2.25±0.71	0.005^a	^aCTL × PRP, P=0.013
					CTL × PRP+SC, P=0.069
					PRP × PRP+SC, P=1.000
Subchondral bone formation	2.20±0.42	2.89±0.33	2.88±0.35	0.002^a	^aCTL × PRP, P=0.032
					^aCTL × PRP+SC, P=0.046
					PRP × PRP+SC, P=1.000
Histological assessment of surface architecture	1.70±0.48	2.89±0.78	3.38±0.52	<0.001^a	^aCTL × PRP, P=0.021
					^aCTL × PRP+SC, P=0.001
					PRP × PRP+SC, P=0.816
Histological assessment of defect filling	4.80±0.42	5.00±0.00	5.00±0.00	0.171	–
Lateral integration of implanted material	2.20±0.42	2.22±0.44	2.50±0.53	0.335	–
Basal integration of implanted material	3.80±0.42	3.89±0.33	3.25±0.46	0.013^a	CTL × PRP, P=1.000
					CTL × PRP+SC, P=0.146
					PRP × PRP+SC, P=0.076
Inflammation maximum total score	1.00±0.00	1.00±0.00	1.00±0.00	1.000	–
Total score	28.10±2.56	34.44±3.88	35.00±2.27	0.001^a	^aCTL × PRP, P=0.008
					^aCTL × PRP+SC, P=0.002
					PRP × PRP+SC, P=1.000

P<0.05. CTL, control group without treatment; PRP, group treated with platelet-rich plasma; PRP + SC, group treated with platelet-rich plasma plus human dental pulp stem cells.