Table II.
Genotype, allele and haplotype distributions of the methylenetetrahydrofolate reductase (MTHFR) gene variants (rs1801131 and rs1801133) in Han Chinese essential tremor patients and controls
| dbSNP ID | Genotype/allele/haplotype | Patients (%) (n=200) | Controls (%) (n=430) | χ2 | P | OR (95% CI) |
|---|---|---|---|---|---|---|
| rs1801131 | AA | 121 (60.5) | 288 (67.0) | |||
| AC | 66 (33.0) | 125 (29.0) | ||||
| CC | 13 (6.5) | 17 (4.0) | 3.437 | 0.179 | ||
| A | 308 (77.0) | 701 (81.5) | ||||
| C | 92 (23.0) | 159 (18.5) | 3.484 | 0.062 | 1.317 (0.986-1.759) | |
| rs1801133 | CC | 85 (42.5) | 154 (35.8) | |||
| CT | 89 (44.5) | 213 (49.5) | ||||
| TT | 26 (13.0) | 63 (14.7) | 2.594 | 0.273 | ||
| C | 259 (64.7) | 521 (60.6) | ||||
| T | 141 (35.3) | 339 (39.4) | 2.012 | 0.156 | 0.837 (0.654-1.071) | |
| rs1801131-rs1801133 | A-C | 42.2 | 42.3 | 0.000 | 0.997 | 1.000 (0.786-1.271) |
| A-T | 34.8 | 39.2 | 2.166 | 0.141 | 0.831 (0.649-1.064) | |
| C-C | 22.6 | 18.3 | 3.241 | 0.072 | 1.306 (0.976-1.749) | |
| C-T | 0.4 | 0.2 | - | - | - |
dbSNP, single nucleotide polymorphism database; OR, odds ratio; CI, confidence interval