Table 4.

Comparison of pharmacokinetic parameters of TAL after oral administration of TAL powder and SNEDDS formulation [F6, I308: TC (1:1)/HCO-30 (1/1)] containing TAL.

Parameter	Unit	TAL Powder	± SEM	TAL SNEDDS	± SEM	% Control
Lambda_z	1/h	0.39	0.03	0.41	0.03	6.11
t1/2	h	1.81	0.17	1.70	0.18	6.00
Tmax	h	1.50	0.00	1.50	0.00	0.00
Cmax	ng/ml	340.75***	27.80	593.05***	36.99	74.04
AUC 0-t	ng/ml∗h	927.35***	56.02	1468.23***	78.29	58.33
AUC 0-t/0-inf_obs		0.94	0.01	0.96	0.01	1.55
MRT 0-inf_obs	H	3.16	0.34	3.06	0.67	3.10
Vz/F_obs	(mg)/(ng/ml)	0.37**	0.84	0.02**	0.001	95.70
Cl/F_obs	(mg)/(ng/ml)/h	0.15*	0.39	0.01*	0.0001	95.594

^∗Data are expressed as mean ± SEM (n = 6), ^∗p < 0.05, ^∗∗p < 0.001, and ^∗∗∗p < 0.0001. T_max, time of peak concentration; C_max, peak of maximum concentration; AUC_0→t, area under the concentration time profile curve up to time 24 h; AUC_0→∞, area under the concentration time profile curve extrapolated to infinity; K_el, elimination rate constant; V_ss, volume of distribution at steady state; T_1/2, half-life; MRT, mean residence time; CL/F, oral clearance.