Table 3.
Blood level of liver enzymes in hepatotoxic rats pretreated with MMCL.
| Treatment | Dose (mg/kg) | ALT (U/L) | AST (U/L) | ALP (U/L) |
|---|---|---|---|---|
| Normal | – | 15.8 ± 3.5 | 95.1 ± 7.3 | 102.7 ± 5.5 |
| 10% DMSO + CCl4 | – | 429.1 ± 81.5a | 513.8 ± 12.0a | 562.3 ± 36.8a |
| NAC + CCl4 | 50 | 191.7 ± 72.7bc | 147.9 ± 27.2bc | 216.7 ± 25.0bc |
| 50 | 634.1 ± 24.1cd | 990.6 ± 39.7cd | 566.7 ± 19.4c | |
| MMCL + CCl4 | 250 | 333.0 ± 15.3c | 723.1 ± 28.9cd | 498.7 ± 68.4c |
| 500 | 168.7 ± 12.0bc | 438.1 ± 16.3bc | 454.7 ± 21.9bc |
Values are expressed as means ± S.E.M. of six replicates.
a
Significantly different when compared with the normal group following treatment with vehicle, p < 0.05.
b
Significantly different when compared with negative control, p < 0.05.
c
Significantly higher when compared with the normal group following treatment with test solutions, p < 0.05.
d
Significantly higher when compared with negative control, p < 0.05.
ALT: alanine amino transaminase; AST: aspartate amino transaminase; ALP: alkaline phosphatase.